International Review of Ophthalmology

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Research progress on scaffold materials and biocompatibility of keratoprosthesis

MA Rui-jie, LI Yan, HU Zhu-lin   

  1. Department of Opthalmology,the Second People’s Hospital of Yunnan Province,  Kunming 650021, China
  • Received:2016-01-21 Online:2016-08-22 Published:2016-09-08
  • Contact: HU Zhu-lin, Email: hzl77@263.com E-mail:hzl77@263.com
  • Supported by:

    Yunnan Medical and Scientific Development Program (2014NS040);Applied Basic Research Programs of Science and Technology Commision Foundation of Yunnan Province (Kunming Medical University Special Program) (2014FB074; 2013FB109)

Abstract:

The most common and traditional treatment options of corneal diseases are penetrating keratoplasty and corneal endothelium transplantation. Moreover, transplantation of keratoprosthesis is an other important therapy method. The most common structure of keratoprosthesis is column lens-nepotism, which is constituted with a transparent optical mirror column in the centre and scaffold in the rim. The key of transplantation of keratoprosthesis lies in the biocompatibility of stent materials. With the development of polymer material science, the kinds of stent materials are increasingly diverse, also  the requirement of biocompatibility is increasingly improved. The current common artificial corneas scaffolds are made with inorganic, organic or/and biological materials. The understanding of the biocompatibility, superiority and inferiority of the different materials could improve the success rate of implantation of keratoprosthesis.